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February 22, 2010

Smokers Double Their Risk for Heart Disease

Filed under: Health, Heart — Tags: — admin @ 9:21 am

A new study offers yet more proof that smoking is a major risk factor for death from heart disease and cancer.

Researchers followed 12,152 American and European male and female smokers, formers smokers and nonsmokers for three years. During that time, current smokers were 4.16 times more likely to die of cancer, 2.26 times more likely to die of heart disease and 2.58 times more likely to die from any cause than were former or nonsmokers. Current smokers were also more likely to suffer a heart attack or stroke.

There were no significant differences between former smokers and nonsmokers in the risk for dying from heart disease or any cause, but former smokers were more likely to die of cancer than those who’d never smoked.

“The analysis provides further strong evidence that people with heart disease who continue to smoke take a very high risk of increasing their chances of death in the short term,” principal investigator Dr. Deepak L. Bhatt, chief of cardiology at the Veterans Affairs Boston Healthcare System, said in a news release from the American Heart Association.

“This study provides impetus for a smoker to stop,” he said. “The benefits of risk reduction accrue relatively quickly when someone stops smoking, although the lingering cancer risk is still there.”

October 19, 2009

Injection May Heal Damaged Heart

Filed under: Heart — admin @ 10:08 am

Doctors have been unable to help injured heart tissue renew itself after a heart attack — until now.

During a heart attack, vessels that supply blood to the heart become blocked, preventing enough oxygen from getting through. The heart muscle dies or is permanently damaged.

But researchers at Children’s Hospital Boston report progress toward someday being ale to regenerate heart tissue after a heart attack or heart failure and even in children who are born with congenital heart defects.

In a study on mice, they showed that neuregulin 1 (NRG1), a growth factor involved in the development of the heart and nervous system, can fuel heart-muscle growth and recovery of cardiac function when injected after a heart attack.

This is a significant development because coronary heart disease, which causes heart attack and angina, is the leading cause of death in America.

After birth, heart-muscle cells stop dividing and proliferating. But experts, led by Dr. Bernhard Kuhn and Kevin Bersell of the cardiology department at Children’s, restarted the cell cycle with NRG1, spurring the heart-muscle cells to divide and make copies of themselves.

When the team injected NRG1 into live mice once a day for three months after the animals had heart attacks, heart regeneration increased and the pumping function improved, compared with untreated mice.

In addition, the NRG1-injected mice did not show some common aftereffects of heart failure.

The study, funded by the cardiology department at Children’s Hospital Boston, the Charles Hood Foundation and the American Heart Association, found that cell growth does not have to come from stem cells. A report on the research appears in the July 24 issue of Cell.

“Although many efforts have focused on stem cell-based strategies, our work suggests that stem cells aren’t required and that stimulating differentiated cardiomyocytes [heart-muscle cells] to proliferate may be a viable alternative,” Kuhn, the study’s senior investigator, said in a news release from the hospital.

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